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860409C

Avanti

9-PAHSA-d9

Avanti Research™ - A Croda Brand 860409C

Synonym(e):

9-[((13,13,14,14,15,15,16,16,16-d9)palmitoyl)hydroxy]-stearic acid

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About This Item

Empirische Formel (Hill-System):
C34H57D9O4
CAS-Nummer:
1809222-43-2
Molekulargewicht:
547.94
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

liquid

Verpackung

pkg of 1 × 1 mL (860409C-1mg)
pkg of 1 × 1 mL (860409C-500ug)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 860409C

Konzentration

0.5 mg/mL (860409C-500ug)
1 mg/mL (860409C-1mg)

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

CCCCCCCCCC(OC(CCCCCCCCCCCC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])=O)CCCCCCCC(O)=O

Verwandte Kategorien

Allgemeine Beschreibung

9-PAHSA-d9 9-[((13,13,14,14,15,15,16,16,16-d9)palmitoyl)hydroxy]-stearic acid is a deuterated palmitoyl hydroxy-stearic acid wherein the nine protons of palmitoyl are replaced by deuterium. Palmitic acid-9-hydroxy-stearic acid (9-PAHSA) is the most abundantly found fatty acid ester of hydroxy fatty acids (FAHFA).
PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes. Avanti has obtained a license from the patent holder to manufacture these products for research use.

Verpackung

5 mL Clear Glass Sealed Ampule (860409C-1mg)
5 mL Clear Glass Sealed Ampule (860409C-500ug)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Zielorgane

Liver,Kidney, Respiratory system

Lagerklassenschlüssel

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

does not flash

Flammpunkt (°C)

does not flash

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Matthew J Kolar et al.
Biochemistry, 55(33), 4636-4641 (2016-08-11)
A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here, we identified and validated carboxyl ester lipase (CEL), a pancreatic enzyme hydrolyzing cholesteryl esters and other dietary
Mark M Yore et al.
Cell, 159(2), 318-332 (2014-10-11)
Increased adipose tissue lipogenesis is associated with enhanced insulin sensitivity. Mice overexpressing the Glut4 glucose transporter in adipocytes have elevated lipogenesis and increased glucose tolerance despite being obese with elevated circulating fatty acids. Lipidomic analysis of adipose tissue revealed the

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