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857393P

Avanti

THI

2-acetyl-5-tetrahydroxybutyl imidazole, powder

Synonym(e):

2-acetyl-4-tetrahydroxybutyl imidazole; 2-acetyl-4(5)-tetrahydroxybutyl imidazole; 2-ATHBI

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About This Item

Empirische Formel (Hill-System):
C9H14N2O5
CAS-Nummer:
94944-70-4
Molekulargewicht:
230.22
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>98% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (857393P-1mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 857393P

Lipid-Typ

sphingolipids
bioactive lipids

Versandbedingung

dry ice

Lagertemp.

−20°C

InChI

1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1

InChIKey

CQSIXFHVGKMLGQ-BWZBUEFSSA-N

Allgemeine Beschreibung

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate lyase (S1P lyase).
Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

Biochem./physiol. Wirkung

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.

Verpackung

5 mL Amber Glass Screw Cap Vial (857393P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Emigration of mature T cells from the thymus is inhibited by the imidazole-based compound 2-acetyl-4-tetrahydroxybutylimidazole.
Gugasyan R, et al.
Immunology, 93, 398-404 (1998)
The immunosuppressive compound 2-acetyl-4-tetrahydroxybutyl imidazole inhibits the allogeneic mixed lymphocyte reaction by sequestration of a recirculating subpopulation of T cells.
Bradbury MG, et al.
Immunology, 87, 80-85 (1996)
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) protects 661W cells against oxidative stress
Fabiani C, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 390(7), 741-751 (2017)
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
Schwab SR, et al.
Science, 309, 1735-1739 (2005)
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy
Nguyen TDH, et al.
Disease models & mechanisms, 7(1), 41-54 (2014)
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