N3386

D-(+)-Neopterin

≥97.5% (sum of enantiomers, HPLC)

• Synonym(e): D-erythro-Neopterin
• Empirische Formel (Hill-System): C₉H₁₁N₅O₄
• CAS-Nummer: 2009-64-5
• Molekulargewicht: 253.21
• Beilstein: 89070
• EG-Nummer: 217-924-7
• MDL-Nummer: MFCD00042801
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 57654449
• NACRES: NA.22

Eigenschaften

• Assay: ≥97.5% (sum of enantiomers, HPLC)
• Form: powder
• Lagertemp.: 2-8°C
• SMILES String: Nc1nc(O)c2nc(cnc2n1)[C@H](O)[C@H](O)CO
• InChI: 1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
• InChIKey: BMQYVXCPAOLZOK-XINAWCOVSA-N

Beschreibung

Allgemeine Beschreibung

D-(+)-Neopterin is a pteridine derivative, naturally found in Dictyostelium discoideum. It is found in significant amounts in the urine of cancer patients.

Anwendung

D-(+)-Neopterin has been used as a NADPH oxidase inhibitor while assessing the ability of NADPH oxidases in breast cancer cells to produce reactive oxygen species (ROS). [NADPH= nicotinamide adenine dinucleotide phosphate]

Biochem./physiol. Wirkung

Pterin cofactor; precursor of BH₄ (tetrahydrobiopterin).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves