933724

Linear polyethylenimine-block-poly(ethylene glycol)

PEG average M_n 5,000, PEI average M_n 10,000

• Synonym(e): PEG-PEI, PEG-b-PEI, Poly(ethylene glycol)-block-polyethylenimine
• Lineare Formel: CH₃(C₂H₄O)_n(C₂H₅N)_mOH
• UNSPSC-Code: 12352207
• NACRES: NA.21

Eigenschaften

• Form: powder or solid
• Qualitätsniveau: 100
• Mol-Gew.: PEG M_n 5,000 Da; PEG average M_n 5,000; PEI M_n 10,000 Da; PEI average M_n 10,000
• Farbe: white to pale yellow
• Lagertemp.: 2-8°C

Beschreibung

Anwendung

Due to their low immunogenicity profiles, polymeric nonviral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable