929867

Linear polyethylenimine-block-poly(ethylene glycol)

PEG average M_n 2,000, PEI average M_n 30,000

• Synonym(e): PEG-b-PEI, PEG-PEI, Poly(ethylene glycol)-block-polyethylenimine
• Lineare Formel: CH₃(C₂H₄O)_n(C₂H₅N)_mOH
• UNSPSC-Code: 12162002
• NACRES: NA.25

Eigenschaften

• Form: powder or solid
• Qualitätsniveau: 100
• Mol-Gew.: PEG M_n 2000 Da; PEG average M_n 2,000; PEI M_n 30000 Da; PEI average M_n 30,000
• Farbe: white to pale yellow
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

Linear polyethylenimine-block-poly(ethylene glycol) (PEG-b-PEI) is a block copolymer of cationic poly(ethylene imine) (PEI) and hydrophilic poly(ethylene glycol) (PEG). PEI is one of the most commonly used cationic polymers for gene delivery applications and PEG improves nucleic acid delivery by producing a stealth barrier.

Anwendung

Due to their low immunogenicity profiles, polymeric non-viral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy.

Leistungsmerkmale und Vorteile

Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable