907286

H-L-Photo-Proline hydrochloride

≥95%, for peptide synthesis

• Synonym(e): (S)-1,2,5-Triazaspiro[2.4]hept-1-ene-6-carboxylic acid, Diazirine amino acid, Photo-Pro, Photo-crosslinking amino acid, Photoprobe building block
• Empirische Formel (Hill-System): C₅H₈ClN₃O₂
• Molekulargewicht: 177.59
• UNSPSC-Code: 12352101
• NACRES: NA.22

Eigenschaften

• product name: H-L-Photo-Proline hydrochloride, ≥95%
• Assay: ≥95%
• Form: powder
• Eignung der Reaktion: reaction type: solution phase peptide synthesis
• Anwendung(en): peptide synthesis
• Lagertemp.: −20°C

Beschreibung

Anwendung

H-L-Photo-Proline HCl is a diazirine-containing proline amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907324.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Sonstige Hinweise

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable