798436

Endo-1-Naphthyl Kwon [2.2.1] Bicyclic Phosphine

• Synonym(e): (1S,4S,5S)-5-(naphthalen-1-yl)-2-tosyl-2-aza-5-phosphabicyclo[2.2.1]heptane
• Empirische Formel (Hill-System): C₂₂H₂₂NO₂PS
• Molekulargewicht: 395.45
• UNSPSC-Code: 12352000
• PubChem Substanz-ID: 329768649
• NACRES: NA.22

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Lagerbedingungen: under inert gas
• Funktionelle Gruppe: phosphine; sulfonamide
• Lagertemp.: 2-8°C
• SMILES String: O=S(N1C[C@H]2[P@@](C3=CC=CC4=C3C=CC=C4)C[C@@H]1C2)(C5=CC=C(C)C=C5)=O
• InChI: 1S/C22H22NO2PS/c1-16-9-11-20(12-10-16)27(24,25)23-14-19-13-18(23)15-26(19)22-8-4-6-17-5-2-3-7-21(17)22/h2-12,18-19H,13-15H2,1H3
• InChIKey: RGHUOMJULXTHPX-UHFFFAOYSA-N

Beschreibung

Anwendung

The bicyclic, chiral phosphine was developed by the Kwon Research Group. Its initial applications were for asymmetric [3+2] annulation between allenes and imines as well as the first examples of phosphine-catalyzed asymmetric syntheses of 1,2,3,5-substituted pyrrolines. Along with nucleophilic organocatalysis, the P-chiral phosphines may also find utility in asymmetric transition-metal catalysis.

Sonstige Hinweise

Hydroxyproline-Derived Pseudoenantiomeric [2.2.1] Bicyclic Phosphines: Asymmetric Synthesis of (+)- and (-)-Pyrrolines

Technology Spotlight- Kwon Phosphines: P-Chiral Monodentate Phosphines from Hydroxyproline

Aldrichimica Acta Review- Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric Annulations

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable