706531
N-Boc-1,2,3,6-Tetrahydropyridin-4-Boronsäurepinakolester
95%
Synonym(e):
(N-tert.-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-boronsäure-pinakolester
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C16H28BNO4
CAS-Nummer:
Molekulargewicht:
309.21
MDL-Nummer:
UNSPSC-Code:
12352103
PubChem Substanz-ID:
NACRES:
NA.22
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Assay
95%
Form
powder
mp (Schmelzpunkt)
100-114 °C
SMILES String
CC(C)(C)OC(=O)N1CCC(=CC1)B2OC(C)(C)C(C)(C)O2
InChI
1S/C16H28BNO4/c1-14(2,3)20-13(19)18-10-8-12(9-11-18)17-21-15(4,5)16(6,7)22-17/h8H,9-11H2,1-7H3
InChIKey
VVDCRJGWILREQH-UHFFFAOYSA-N
Verwandte Kategorien
Allgemeine Beschreibung
Boc-THP-Bpin is frequently used in metal catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Negishi couplings.
Anwendung
Reagent used for
Reagent used in Preparation of several enzymatic inhibitors and receptor ligands
- Suzuki-Miyaura cross-coupling using palladium phosphine catalyst
- Palladium-catalyzed ligand-controlled regioselective Suzuki coupling
- Palladium-catalyzed Suzuki-Miyaura coupling
- Suzuki coupling followed by iodolactonization reaction
- Wrenchnolol derivative optimized for gene activation in cells
Reagent used in Preparation of several enzymatic inhibitors and receptor ligands
- Orally active anaplastic lymphoma kinase inhibitors
- Oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes
- 4-arylpiperidinyl amides and N-arylpiperidin-3-yl-cyclopropanecarboxamides as novel melatonin receptor ligands
- Quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for treatment of Gaucher disease, a lysosomal storage disorder
- Arylpiperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Gaucher disease is a lysosomal storage disorder (LSD) caused by deficiency in the enzyme glucocerebrosidase (GC). Small molecule chaperones of protein folding and translocation have been proposed as a promising therapeutic approach to this LSD. Most small molecule chaperones described
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