525057
4-Pyrazolborsäurepinacolester
97%
Synonym(e):
4,4,5,5-Tetramethyl-2-(1H-pyrazol-4-yl)-1,3,2-dioxaborolan
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Alle Fotos(3)
About This Item
Lineare Formel:
(CH3)4C2O2BC3N2H3
CAS-Nummer:
Molekulargewicht:
194.04
MDL-Nummer:
UNSPSC-Code:
12352103
PubChem Substanz-ID:
NACRES:
NA.22
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Qualitätsniveau
Assay
97%
Form
solid
mp (Schmelzpunkt)
142-146 °C (lit.)
SMILES String
CC1(C)OB(OC1(C)C)c2cn[nH]c2
InChI
1S/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)
InChIKey
TVOJIBGZFYMWDT-UHFFFAOYSA-N
Verwandte Kategorien
Anwendung
Reagent used for
Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
- Suzuki-Miyaura cross-couplings
- Ruthenium-catalyzed asymmetric hydrogenation
Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
- VEGF
- Aurora
- Rho (ROCK)
- Janus Kinase 2 (JAK)
- c-MET
- ALK
- S-nitrosoglutathione reductase
- CDC7
- Acetyl-CoA carboxylase
- Prosurvival Bcl-2 protein
- Viral RNA-Dependent RNA polymerase
- Long Chain Fatty Acid Elongase 6
- PI3
- AKT
- Chk1
- Protein Kinase B
Rechtliche Hinweise
Product of Boron Molecular
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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A ligand-based 3D pharmacophore model for serine/threonine kinase CDC7 inhibition was created and successfully applied in the discovery of novel 2-(heteroaryl)-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-ones. The pharmacophore model provided a hypothesis for lead generation missed by docking to a homology model. Medicinal chemistry exploration
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Michael L Curtin et al.
Bioorganic & medicinal chemistry letters, 22(9), 3208-3212 (2012-04-03)
In an effort to identify multi-targeted kinase inhibitors with a novel spectrum of kinase activity, a screen of Abbott proprietary KDR inhibitors against a broad panel of kinases was conducted and revealed a series of thienopyridine ureas with promising activity
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Bioorganic & medicinal chemistry letters, 21(5), 1325-1328 (2011-02-09)
Overexpression of prosurvival or underexpression of pro-death Bcl-2 family proteins can lead to cancer cell resistance to chemotherapy and radiation treatment. Inhibition of the prosurvival Bcl-2 family proteins has become a strategy for cancer therapy and inhibitors are currently being
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