35840

Methyldichloracetat

≥99%

• Synonym(e): Methyl-dichloracetat, NSC 2882
• Lineare Formel: Cl₂CHCOOCH₃
• CAS-Nummer: 116-54-1
• Molekulargewicht: 142.97
• Beilstein: 1747542
• EG-Nummer: 204-146-8
• MDL-Nummer: MFCD00000843
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24861975
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥99%
• Form: liquid
• Brechungsindex: n20/D 1.442 (lit.)
• bp: 143 °C (lit.)
• mp (Schmelzpunkt): −52 °C (lit.)
• Dichte: 1.381 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: chloro; ester
• SMILES String: COC(=O)C(Cl)Cl
• InChI: 1S/C3H4Cl2O2/c1-7-3(6)2(4)5/h2H,1H3
• InChIKey: HKMLRUAPIDAGIE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Methyl dichloroacetate undergoes base-catalyzed condensation with aliphatic α-haloaldehydes. Chlorination of methyl dichloroacetate by using trifluoromethanesulfonyl chloride has been reported.

Anwendung

Methyl dichloroacetate may be used:

• in the diastereoselctive synthesis of bicyclic chlorocyclopropane
• as difunctional initiator during atom transfer radical polymerization of methyl or n-butyl acrylate
• as reagent during CrCl₂-induced olefination of aldehydes

Reactant involved in:

• Nucleophilic substitution reactions with nitro(pentafluorosulfanyl)benzenes
• Azide-alkyl halide cycloaddition and atom transfer radical addition
• Chemical modification of STn antigen for enhancement of synthetic carbohydrate vaccines
• Three component reaction of arynes with cyclic ethers and active methines
• Catalytic radical haloalkylation for synthesis of neodysidenin
• Addition reactions for syntehsis of enantiopure 3,4-diamino esters or amides

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H332,H335
• P-Sätze: P261 - P264 - P271 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): 147.2 °F - closed cup
• Flammpunkt (°C): 64 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter