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224588

Sigma-Aldrich

5-Chloruracil

ReagentPlus®, 99%

Synonym(e):

5-Chlor-2,4-dihydroxy-pyrimidin, 5-Chlorpyrimidin-2,4(1H,3H)-dion

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About This Item

Empirische Formel (Hill-System):
C4H3ClN2O2
CAS-Nummer:
1820-81-1
Molekulargewicht:
146.53
Beilstein:
127173
EG-Nummer:
217-339-7
MDL-Nummer:
MFCD00006019
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24853447
NACRES:
NA.22

Qualitätsniveau

100

Produktlinie

ReagentPlus®

Assay

99%

Form

solid

mp (Schmelzpunkt)

>300 °C (lit.)

Löslichkeit

1 M NH4OH: soluble 50 mg/mL

Funktionelle Gruppe

chloro

SMILES String

ClC1=CNC(=O)NC1=O

InChI

1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChIKey

ZFTBZKVVGZNMJR-UHFFFAOYSA-N

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Verwandte Kategorien

Allgemeine Beschreibung

The shape resonance spectra of 5-chlorouracil, obtained from fixed-nuclei elastic scattering calculations by the Schwinger multichannel method with pseudopotentials, was studied.

Anwendung

5-Chlorouracil was used as a control in resazurin-based cytotoxicity assay for screening of cytotoxicity in hepatocytes and liver cell lines.

Rechtliche Hinweise

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

H-Sätze

H301,H341

Gefahreneinstufungen

Acute Tox. 3 Oral - Muta. 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
04617AJ
4204PH
01111AJ
15323DB
17110

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Die Dokumentenbibliothek aufrufen

F Kossoski et al.
The Journal of chemical physics, 140(2), 024317-024317 (2014-01-21)
We report on the shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil, as obtained from fixed-nuclei elastic scattering calculations performed with the Schwinger multichannel method with pseudopotentials. Our results are in good agreement with the available electron transmission spectroscopy data
M K McMillian et al.
Cell biology and toxicology, 18(3), 157-173 (2002-06-27)
A simple resazurin-based cytotoxicity assay is presented for screening of cytotoxicity in hepatocytes and liver cell lines. Human hepatoma (HepG2) cells in 96-well culture plates were exposed to known toxic (cisplatin, 5-fluorouracil, ethionine, flufenamic acid, and diflunisal) and control (transplatin
Anionradicals from 5-halouracil substituted oriented DNA after X-irradiation at low temperatures.
K Voit et al.
Radiation and environmental biophysics, 25(3), 175-181 (1986-01-01)
T Sato et al.
Environmental and molecular mutagenesis, 17(4), 258-263 (1991-01-01)
The SOS chromotest was applied for the detection of antimutagens. To raise SOS induction, the bacteria were treated with the mutagens, UV, 4-nitroquinoline N-oxide (4NQO), N-methyl-N'-nitro-N-nitroso-guanidine (MNNG), or benzo[a]pyrene (B[a]p). The inhibitory effects of L-ascorbic acid, glutathione, vanillin, 5-fluorouracil (5-FU)
S M Morris
Mutation research, 297(1), 39-51 (1993-07-01)
The halogenated pyrimidines were synthesized in the 1950s as potential anti-tumor agents after the discovery that certain tumors preferentially incorporated uracil rather than thymine into the DNA. The fluorinated derivatives are widely recognized today as effective treatment modalities, especially with
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