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914134

Sigma-Aldrich

5-(Biotinamido)pentylamine TFA Salt

≥95%

Sinónimos:

N-(5-Aminopentyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pent, Biotin cadaverine TFA, Biotin-DAPe TFA

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About This Item

Fórmula empírica (notación de Hill):
C15H28N4O2S · xC2HF3O2
Peso molecular:
328.47 (free base basis)
MDL number:
MFCD03452814
UNSPSC Code:
12352116
NACRES:
NA.22

Quality Level

100

assay

≥95%

form

powder

mp

116-121 °C

storage temp.

2-8°C

SMILES string

FC(F)(F)C(=O)O.S1[C@H]([C@H]2NC(=O)N[C@H]2C1)CCCCC(=O)NCCCCCN

InChI key

QWKKJNXOPDNIEU-RGESYUBESA-N

Application

5-(Biotinamido)pentylamine TFA Salt is a versatile biotinylated linker that can be incorporated into chemical tools via its terminal amino group. Labeling materials or proteins with biotin provides a means to enrich and capture targets from biological systems.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation

Synthesis of Novel Phosphonic-Type Activity-Based Probes for Neutrophil Serine Proteases and Their Application in Spleen Lysates of Different Organisms

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Sung Kook Chun et al.
ACS chemical biology, 9(3), 703-710 (2014-01-07)
Circadian rhythms, biological oscillations with a period of about 24 h, are maintained by a genetically determined innate time-keeping system called the molecular circadian clockwork. Despite the physiological and clinical importance of the circadian clock, the development of small molecule
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Chemical communications (Cambridge, England), (4), 398-400 (2007-01-16)
Coenzyme A analogues are synthesized in a one-pot preparation by biotransformation of pantothenate thioesters through the simultaneous use of three CoA biosynthetic enzymes, followed by aminolysis.
Taiki Yokoi et al.
Chemical communications (Cambridge, England), 55(13), 1891-1894 (2018-12-21)
This paper reports the selective conversion of alkyl azido groups at the carbonyl α-position into oximes through β-elimination of dinitrogen, followed by transoximation. With this method and diazo conversion, a triazido molecule was transformed into a triple click conjugation scaffold
Collette S Guy et al.
Organic & biomolecular chemistry, 17(43), 9524-9528 (2019-10-30)
Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need
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Chemical communications (Cambridge, England), 50(6), 664-666 (2013-11-28)
A facile and useful method for preparing caged DNAs was developed. The method includes a caging reaction of a linear dsDNA having a minimal sequence of protein expression with Bio-Bhc-diazo and affinity separation of the caged DNA. Effective suppression and
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