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SCP0157

Sigma-Aldrich

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP)

Synonym(s):

GRGDSP Peptide, RGD Peptide

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About This Item

Empirical Formula (Hill Notation):
C22H37N9O10
Molecular Weight:
587.58
UNSPSC Code:
12352209
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥60%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro

General description

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is a bioactive molecule/peptide derived from fibronectin.

Application

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) has been used:
  • in coating well plate to monitor cell attachment by crystal violet staining
  • to treat baby hamster kidney (BHK-21) cells to study the role of Arg-Gly-Asp (RGD) motif in the replication of Japanese encephalitis virus (JEV)
  • to block RGD-dependent integrins or integrin signaling in INA-6 cells
  • to study the role of the RGD-binding integrins in Gal-3-mediated cell adhesion

Biochem/physiol Actions

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can stimulate endothelialization by modifying the surface of cardiovascular implants. The major cell- binding domain of GRGDSP helps to promote cell adhesion on a wide range of substrates.
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shyam Patel et al.
Journal of biomedical materials research. Part A, 83(2), 423-433 (2007-04-25)
Vascular endothelium plays an important role in preventing thrombogenesis. Bioactive molecules such as fibronectin-derived peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Here we conjugated GRGDSP peptide to
Ines Lauria et al.
Acta biomaterialia, 62, 317-327 (2017-09-03)
Bionanoparticles based on filamentous phages or flexuous viruses are interesting candidates for meeting the challenges of tailoring biomineralization in hydrogel-based bone tissue substitutes. We hypothesized that hydroxyapatite crystal nucleation and matrix mineralization can be significantly increased by mineralization-inducing (MIP) and
Julia Dotterweich et al.
Cell communication and signaling : CCS, 12, 36-36 (2014-06-27)
CCN family member 1 (CCN1), also known as cysteine-rich angiogenic inducer 61 (CYR61), belongs to the extracellular matrix-associated CCN protein family. The diverse functions of these proteins include regulation of cell migration, adhesion, proliferation, differentiation and survival/apoptosis, induction of angiogenesis
Antonín Sedlář et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Galectin-3 (Gal-3) is a β-galactoside-binding protein that influences various cell functions, including cell adhesion. We focused on the role of Gal-3 as an extracellular ligand mediating cell-matrix adhesion. We used human adipose tissue-derived stem cells and human umbilical vein endothelial

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