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Key Documents

SAB4501038

Sigma-Aldrich

Anti-MTOR antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FRAP, FRAP1, FRAP2, RAFT1, Rapamycin target protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 2888 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P42345

UniProt accession no.

P42345

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MTOR(2475)

General description

Anti-MTOR antibody detects endogenous levels of total MTOR protein.
The mechanistic/mammalian target of rapamycin (mTOR) is a serine/threonine kinase. It is a member of the phosphatidylinositide 3-kinases (PI 3-kinases or PI3Ks) family. It is mapped to human chromosome 1p36.22.

Immunogen

The antiserum was produced against synthesized peptide derived from human mTOR.

Immunogen Range: 2447-2496

Application

Anti-MTOR, C-Terminal antibody has been used in western blotting.

Biochem/physiol Actions

The mechanistic/mammalian target of rapamycin (mTOR) controls protein translation, cell growth, survival, invasion and metabolism. It acts as an intracellular signalling regulator which links the extracellular events to the intracellular process. mTOR also acts on the protein synthesis machinery.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lexing Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(4), 1723-1734 (2018-08-06)
Autophagy is a process of evolutionarily conservative degradation, which could maintain cellular homeostasis and cope with various types of stress. LncRNAs are considered as competing endogenous RNAs (ceRNAs) contributing to autophagy. GAS5 has been suggested as a new potential factor
Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition
Marques-Ramos A, et al.
RNA (2017)
The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma
Miyahara H, et al.
Cancer Letters, 400, 110-116 (2017)
Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course
Jia W, et al.
Anticancer Research, 33(8), 3123-3131 (2013)
Fengling Song et al.
Journal of cellular physiology, 234(5), 7420-7434 (2018-10-27)
Long noncoding RNA urothelial carcinoma associated 1 (UCA1) has been implicated in the growth and metastasis of colorectal cancer (CRC), and autophagy contributes to tumorigenesis and cancer cell survival. However, the regulatory role of UCA1 in CRC cell viability by
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