PZ0114

PD-166866

≥98% (HPLC)

• Synonym(s): 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea
• Empirical Formula (Hill Notation): C₂₀H₂₄N₆O₃
• CAS Number: 192705-79-6
• Molecular Weight: 396.44
• MDL number: MFCD12922514
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823706
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• color: off-white to light tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C
• InChI: 1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
• InChI key: NHJSWORVNIOXIT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC₅₀ = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable