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Key Documents

L8662

Sigma-Aldrich

L-Lysine monohydrochloride

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

Synonym(s):

(S)-2,6-Diaminohexanoic acid monohydrochloride

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About This Item

Linear Formula:
H2N(CH2)4CH(NH2)CO2H·HCl
CAS Number:
Molecular Weight:
182.65
Beilstein:
3563889
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

L-Lysine monohydrochloride, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

biological source

non-animal source

Quality Level

Agency

meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

263 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

application(s)

pharmaceutical (small molecule)

SMILES string

OC([C@@H](N)CCCCN)=O.[H]Cl

InChI

1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1

InChI key

BVHLGVCQOALMSV-JEDNCBNOSA-N

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Application


  • Scientific opinion on the presence of DNA in the feed additives consisting of concentrated liquid l-lysine, l-lysine monohydrochloride and concentrated liquid l-lysine monohydrochloride produced by Escherichia coliNITE BP-02917 for all animal species (METEX NOOVISTAGO).: This study explores the presence of DNA in l-lysine monohydrochloride and its variants used in animal feed, addressing safety concerns associated with genetic material in feed products (EFSA Panel et al., 2023).

  • Safety and efficacy of a feed additive consisting of concentrated liquid l-lysine, l-lysine monohydrochloride and concentrated liquid l-lysine monohydrochloride produced by Escherichia coliNITE BP-02917 for all animal species (Metex NoovistaGo).: Evaluates the safety and efficacy of l-lysine monohydrochloride in animal feed, contributing to a better understanding of its use and regulatory compliance (EFSA Panel et al., 2022).

  • Safety and efficacy of a feed additive consisting of l-lysine monohydrochloride and l-lysine sulfate produced by fermentation with Corynebacterium glutamicumCGMCC 17927 for all animal species (Barentz Animal Nutrition B.V.).: This publication assesses the safety and effectiveness of l-lysine monohydrochloride and l-lysine sulfate in various animal feeds, ensuring they meet health and nutritional standards (EFSA Panel et al., 2022).

  • Safety and efficacy of a feed additive consisting of l-lysine monohydrochloride and l-lysine sulfate produced by Corynebacterium glutamicum CGMCC 14498 for all animal species (Kempex Holland BV).: Investigates the implications of using l-lysine monohydrochloride and l-lysine sulfate in feed, focusing on their impact on animal health and growth (EFSA Panel et al., 2021).

  • Safety and efficacy of the feed additives concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by Corynebacterium glutamicum KCCM 80183 for all animal species (CJ Europe GmbH).: Analyzes the safety and benefits of concentrated liquid l-lysine and l-lysine monohydrochloride, detailing their advantages and regulatory approval for use in feed (EFSA Panel et al., 2021).


Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Guntur Fibriansah et al.
Nature communications, 6, 6341-6341 (2015-02-24)
Dengue virus (DENV) infects ~400 million people annually. There is no licensed vaccine or therapeutic drug. Only a small fraction of the total DENV-specific antibodies in a naturally occurring dengue infection consists of highly neutralizing antibodies. Here we show that
Amélie Fradet-Turcotte et al.
Nature, 499(7456), 50-54 (2013-06-14)
53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand-break (DSB) repair by non-homologous end joining. To accomplish its function in DNA repair, 53BP1 accumulates at DSB sites downstream of the RNF168 ubiquitin ligase.
Alexander Leitner et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9455-9460 (2014-06-19)
The study of proteins and protein complexes using chemical cross-linking followed by the MS identification of the cross-linked peptides has found increasingly widespread use in recent years. Thus far, such analyses have used almost exclusively homobifunctional, amine-reactive cross-linking reagents. Here
Chunaram Choudhary et al.
Nature reviews. Molecular cell biology, 15(8), 536-550 (2014-07-24)
Lysine acetylation is a conserved protein post-translational modification that links acetyl-coenzyme A metabolism and cellular signalling. Recent advances in the identification and quantification of lysine acetylation by mass spectrometry have increased our understanding of lysine acetylation, implicating it in many
Przemyslaw Nogly et al.
IUCrJ, 2(Pt 2), 168-176 (2015-04-14)
Lipidic cubic phases (LCPs) have emerged as successful matrixes for the crystallization of membrane proteins. Moreover, the viscous LCP also provides a highly effective delivery medium for serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs). Here, the adaptation of

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