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QBD10776

Sigma-Aldrich

dPEG®48-biotin acid

>90% (HPLC)

Synonym(s):

Biotin-PEG-acid, Biotin-PEG48-COOH, PEG2000 biotin acid, PEG48-biotin acid

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About This Item

Empirical Formula (Hill Notation):
C112H218N4O53S
Molecular Weight:
2500.99
UNSPSC Code:
12352106
NACRES:
NA.22

Assay

>90% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Biotinylations
reaction type: Pegylations

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

Features and Benefits

dPEG48 biotin acid is a 2,500 Dalton biotin acid product that contains a 157 atom (187.8 Å) dPEG spacer. Amphiphilic dPEG48 biotin acid dissolves in water or aqueous buffer and organic solvents. It does not cause aggregation or precipitation of biomolecules. Using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry, dPEG48 biotin acid couples to free primary amines in aqueous media. These free amines can be on a protein, peptide, or the treated surface of a nanoparticle. Moreover, the terminal propionic acid moiety can be functionalized with other reactive groups for coupling directly to surfaces such as glass, gold, or magnetic nanoparticles. dPEG48 biotin acid is a monodisperse equivalent of the polymeric PEG2000.

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Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Thurid Boetel et al.
Biochemical and biophysical research communications, 349(1), 296-302 (2006-08-29)
The biological function of prion protein (PrP) and the physiological relevance of its truncated subtypes and glycoforms is still enigmatic. In this paper, we adduce evidence that recombinant murine PrP fragment 90-231 (mPrP90-231) contains a biotin-mimicking sequence motif that causes
Alexander Kuzmin et al.
Bioconjugate chemistry, 21(11), 2076-2085 (2010-10-23)
The utility of catalyst-free azide-alkyne [3 + 2] cycloaddition for the immobilization of a variety of molecules onto a solid surface and microbeads was demonstrated. In this process, the surfaces are derivatized with aza-dibenzocyclooctyne (ADIBO) for the immobilization of azide-tagged

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