934321
L-Valyl-L-citrulline
≥95%
Synonym(s):
L-Valyl-N5-(aminocarbonyl)-L-ornithine, Val-Cit
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About This Item
Empirical Formula (Hill Notation):
C11H22N4O4
CAS Number:
Molecular Weight:
274.32
UNSPSC Code:
12352209
NACRES:
NA.21
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Application
This is a cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC & Bioconjugation).
Features and Benefits
Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. The Boc group can be deprotected under acidic conditions to generate a free amine group. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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