934372
MC-Val-Cit-PAB-PNP
≥95%
Synonym(s):
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
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About This Item
Empirical Formula (Hill Notation):
C35H43N7O11
CAS Number:
Molecular Weight:
737.76
Beilstein:
10322169
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22
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Application
This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).
Features and Benefits
The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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