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T7569

Sigma-Aldrich

Anti-phospho-Tau (pSer262) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-DDPAC, Anti-FTDP-17, Anti-MAPTL, Anti-MSTD, Anti-MTBT1, Anti-MTBT2, Anti-PPND, Anti-PPP1R103, Anti-TAU

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About This Item

MDL number:
MFCD03455773
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

rat, mouse, human

technique(s)

western blot: 1:1,000

UniProt accession no.

P10636

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer262)

Gene Information

human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)

General description

Tau (τ), also known as MAPT (microtubule associated protein tau) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons.

Immunogen

chemically synthesized phosphopeptide derived from the region of human tau that contains serine262.

Biochem/physiol Actions

Removal of Tau (τ) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). Tau helps in the assembly and maintenance of microtubule structure. Measurement of phosphorylated tau (P-tau) levels in cerebrospinal fluid (CSF) acts a potential marker for differentiation between AD and dementia with Lewy bodies (DLB).

Physical form

Supplied in 100 μL of Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies
Parnetti L
Neurological Sciences, 22, 77-78 (2001)
Linkage Disequilibrium and Association of MAPT H1 in Parkinson Disease
Skipper L
American Journal of Human Genetics, 2004, 669-677 (2004)
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability.
Shaw-Smith C
Nature Genetics, 38, 1032-1037 (2006)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Myers AJ
Human Molecular Genetics, 14, 2399-2404 (2005)
S M Jenkins et al.
The Biochemical journal, 345 Pt 2, 263-270 (2000-01-06)
Tau is a microtubule-associated protein that is functionally modulated by phosphorylation and hyperphosphorylated in several neurodegenerative diseases. Because phosphorylation regulates both normal and pathological tau functioning, it is of great interest to identify the signalling pathways and enzymes capable of

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