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SML2556

Sigma-Aldrich

Pt-ttpy

>97% (NMR)

Synonym(s):

(SP-4-2)-Chloro[4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine-κN1,κN1′,κN1′′]-Platinum(1+) chloride, Tolylterpyridin-platin

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About This Item

Empirical Formula (Hill Notation):
C22H17Cl2N3Pt
CAS Number:
727721-37-1
Molecular Weight:
589.37
UNSPSC Code:
12352200

Assay

>97% (NMR)

form

powder

color

faint yellow to dark orange

solubility

DMSO: 0.2 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

CC1=CC=C(C2=CC(C3=[N+]4C=CC=C3)=[N+]5C(C6=CC=CC=[N+]6[Pt-2]54Cl)=C2)C=C1.[Cl-]

Biochem/physiol Actions

Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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