SML2170

HX531

≥98% (HPLC)

• Synonym(s): 4-(5H-2,3-(2,5-dimethyl-2,5-hexano)-5-methyl- 8-nitrodibenzo[b,e][1,4]diazepin-11-yl)benzoic acid, 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid, HX 531, HX-531
• Empirical Formula (Hill Notation): C₂₉H₂₉N₃O₄
• CAS Number: 188844-34-0
• Molecular Weight: 483.56
• MDL number: MFCD19690920
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN(C1=CC2=C(C(C)(CCC2(C)C)C)C=C13)C(C=C4)=C(N=C3C5=CC=C(C=C5)C(O)=O)C=C4[N+]([O-])=O
• InChI: 1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)
• InChI key: SXKPGYKPQPYJER-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Antagonist of the retinoid X receptor (RXR)

HX-531 is a potent antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM. HX531 has been used in many studies of the various effects of retinoids and RXR activity in diseases such as diabetes, Parkinson′s disease, often as a control for agonists such as Bexarotene. It was recently shown to promote white adipogenic differentiation and inhibit both basal and Bexarotene-induced brown adipogenic differentiation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable