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SML0264

Sigma-Aldrich

AEG 3482

≥98% (HPLC)

Synonym(s):

6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

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About This Item

Empirical Formula (Hill Notation):
C10H8N4O2S2
CAS Number:
63735-71-7
Molecular Weight:
280.33
MDL number:
MFCD02064987
UNSPSC Code:
12352200
PubChem Substance ID:
329825272
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3

InChI

1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)

InChI key

MQUYTXDAVCOCMX-UHFFFAOYSA-N

Biochem/physiol Actions

AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
022M4741V

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Amir H Salehi et al.
Chemistry & biology, 13(2), 213-223 (2006-02-24)
We describe a group of small-molecule inhibitors of Jun kinase (JNK)-dependent apoptosis. AEG3482, the parental compound, was identified in a screening effort designed to detect compounds that reduce apoptosis of neonatal sympathetic neurons after NGF withdrawal. We show that AEG3482
Karthiga Santhana Kumar et al.
SpringerPlus, 4, 19-19 (2015-01-28)
Medulloblastoma (MB) comprises four molecularly and genetically distinct subgroups of embryonal brain tumors that develop in the cerebellum. MB mostly affects infants and children and is difficult to treat because of frequent dissemination of tumor cells within the leptomeningeal space.
Zhen Ning Wee et al.
Nature communications, 6, 8746-8746 (2015-10-28)
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in a subset of breast cancers, in particular triple-negative breast cancer (TNBC), where

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