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SML0246

Sigma-Aldrich

Tirofiban hydrochloride monohydrate

≥98% (HPLC)

Synonym(s):

L 700462, MK 383, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine

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About This Item

Empirical Formula (Hill Notation):
C22H36N2O5S·HCl·H2O
CAS Number:
150915-40-5
Molecular Weight:
495.07
MDL number:
MFCD07368623
UNSPSC Code:
12352200
PubChem Substance ID:
329825256
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -10 to -18° (c=1, MeOH)

storage condition

desiccated

color

white to beige

solubility

DMSO: >12 mg/mL at warmed to 60 °C

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC([C@@H](NS(CCCC)(=O)=O)CC1=CC=C(C=C1)OCCCCC2CCNCC2)=O.Cl.O

InChI

1S/C22H36N2O5S.ClH.H2O/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H;1H2/t21-;;/m0../s1

InChI key

HWAAPJPFZPHHBC-FGJQBABTSA-N

Gene Information

human ... ITGA2B(3674) , ITGB3(3690)

Application

Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.

Biochem/physiol Actions

Tirofiban hydrochloride is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. Blocks platelet aggregation and thrombus formation.
Tirofiban might cause thrombocytopenia.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yu-Lun Tseng et al.
Toxicology and applied pharmacology, 364, 106-113 (2018-12-29)
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Xia Hong et al.
Journal of clinical laboratory analysis, 30(2), 108-113 (2014-11-27)
Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to reduce the incidence of thrombotic adverse events and hemorrhagic complications. And this
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
Inhibition of the integrin signal constitutes a mouse iPS cell niche.
Higuchi S, et al.
Development, Growth & Differentiation, 58(7), 586-599 (2016)
C J Panebianco et al.
European cells & materials, 39, 211-226 (2020-05-13)
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