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Key Documents

SAB4504499

Sigma-Aldrich

Anti-phospho-p53 (pSer15) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-BCC7, Anti-BMFS5, Anti-LFS1, Anti-P53, Anti-TRP53

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 43 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P04637

UniProt accession no.

P04637

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer15)

Gene Information

human ... TP53(7157)

General description

TP53 (tumor protein p53) gene is located on human chromosome 17p13.1. This is a tumor-suppressor gene.

Immunogen

The antiserum was produced against synthesized peptide derived from human p53 around the phosphorylation site of Ser15.

Immunogen Range: 1-50

Biochem/physiol Actions

TP53 (tumor protein p53) gene is required for the DNA-damage checkpoint.This protein controls cell cycle, senescence and apoptosis upon oncogene activation, stress and DNA damage. Mutation in TP53 results in breast cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Assessing TP53 status in human tumours to evaluate clinical outcome.
Soussi T and Beroud C
Nature Reviews. Cancer, 1(3), 233-233 (2001)
Wip1 phosphatase: between p53 and MAPK kinases pathways.
Goloudina AR, et al.
Oncotarget, 7(21), 31563-31571 (2016)
TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting.
Fountzilas G, et al.
Oncotarget, 7(22), 32731-32753 (2016)
Takahiro Isono et al.
PloS one, 9(5), e96168-e96168 (2014-05-07)
Some cancer cells can survive under glucose deprivation within the microenvironment of a tumor. Recently, we reported that N-linked (β-N-acetylglucosamine)2 [N-GlcNAc2]-modified proteins induce G2/M arrest and cell death under glucose deprivation. Here, we investigated whether such a response to glucose
Meaghan D Waltmann et al.
Biochimica et biophysica acta, 1842(9), 1395-1405 (2014-05-21)
Genome-wide association studies have linked LRP8 polymorphisms to premature coronary artery disease and myocardial infarction in humans. However, the mechanisms by which dysfunctions of apolipoprotein E receptor-2 (apoER2), the protein encoded by LRP8 gene, influence atherosclerosis have not been elucidated

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