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SAB4500351

Sigma-Aldrich

Anti-Histone H3 (Acetyl-Lys27) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

H3/a, H3/c, H3/d, H3/f, H3/h

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 15 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

P68431

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

acetylation (Lys27)

Gene Information

human ... HIST1H3A(8350)

General description

Anti-Histone H3 (Acetyl-Lys27) Antibody detects endogenous levels of total Histone H3 (Acetyl-Lys27) protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Histone H3 around the acetylated site of Lys27.

Immunogen Range: 11-60

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Romain Pacaud et al.
Theranostics, 5(1), 12-22 (2015-01-02)
Histones post-translational modifications (PTMs) are crucial components of diverse processes that modulate chromatin. Among the histones PTMs, the histones phosphorylation appears such crucial since it plays a significant role into DNA repair structure, transcription and chromatin compaction during cell division
Athanasios Lourbopoulos et al.
Journal of molecular neuroscience : MN, 54(1), 78-91 (2014-03-01)
Thyroid hormones (TH) and receptors (TRs) may play an important role in the pathophysiology of acute cerebral ischemia. In the present study, we sought to determine whether serum triodothyronine (T3)/thyroxine (T4) and brain TRs (TRα1, TRβ1) might change after experimental
Toshiaki Iba et al.
Thrombosis research, 134(1), 169-173 (2014-05-13)
The activation of coagulation is recognized as a universal event in severe sepsis. Both antithrombin and thrombomodulin play pivotal roles as suppressors of coagulation. Since the levels of both anticoagulants decrease significantly, we hypothesized that a combination therapy would be
Leike Xie et al.
Investigative ophthalmology & visual science, 55(8), 4731-4740 (2014-07-06)
Posterior capsule opacification (PCO) after cataract surgery is due in part to proliferation of the adhering lens epithelial cells and transdifferentiation into mesenchymal cells. The histone deacetylase (HDAC) inhibitors, trichostatin A (TSA) and vorinostat (suberoylanilidehydroxamic acid [SAHA]) are known to
Ahrom Ham et al.
American journal of physiology. Renal physiology, 307(9), F1052-F1062 (2014-08-29)
Peptidyl arginine deiminase (PAD)4 is a nuclear enzyme that catalyzes the posttranslational conversion of arginine residues to citrulline. Posttranslational protein citrullination has been implicated in several inflammatory autoimmune diseases, including rheumatoid arthritis, colitis, and multiple sclerosis. Here, we tested the
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