SAB4300077

Anti-phospho-TP53 (pSer³⁷) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-FLJ92943 antibody produced in rabbit, Anti-LFS1 antibody produced in rabbit, Anti-TRP53 antibody produced in rabbit, Anti-p53 antibody produced in rabbit, Anti-tumor protein p53 antibody produced in rabbit
• MDL number: MFCD00164709
• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~53 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (L-P-SP-Q-A)
• NCBI accession no.: NP_000537.3
• UniProt accession no.: P04637
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer37)
• Gene Information: human ... TP53(7157)

Description

Immunogen

Peptide sequence around phosphorylation site of serine 37 (L-P-S(p)-Q-A), according to the protein TP53.

Features and Benefits

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Target description

p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable