RAB0441
Phospho-Stat1 (pSer727) and pan-Stat1 ELISA Kit
for detection of phospho-stat1 (pSer727) and pan-stat1 in human or mouse cell and tissue lysates
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
mouse, human
technique(s)
ELISA: suitable
capture ELISA: suitable
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... STAT1(6772)
mouse ... STAT1(20846)
General description
The Phospho-Stat1 (pSer727) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Immunogen
Stat1 (pTyr727) synthetic phosphopeptide, Recombinant Human STAT1
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.
Signal Word
Warning
Hazard Statements
Hazard Classifications
Met. Corr. 1 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
8A - Combustible corrosive hazardous materials
Certificates of Analysis (COA)
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Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.
Townsend PA
Faseb Journal, 18(13), 1621-1623 (2004)
Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance.
Hong S
Journal of Virology, 85(18), 9486-9494 (2011)
STAT-1: a novel regulator of apoptosis.
Stephanou A and Latchman DS
International Journal of Experimental Pathology, 84(6), 239-244 (2003)
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