I127

ICI 118,551 hydrochloride

≥98% (HPLC), powder, β2 inverse agonist

• Synonym(s): (2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride
• Empirical Formula (Hill Notation): C₁₇H₂₇NO₂ · HCl
• CAS Number: 72795-01-8
• Molecular Weight: 313.86
• MDL number: MFCD00153812
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277782
• NACRES: NA.77

Properties

• product name: ICI 118,551 hydrochloride, ≥98% (HPLC), powder
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: H₂O: >10 mg/mL
• SMILES string: Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
• InChI: 1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1
• InChI key: KBXMBGWSOLBOQM-LINSIKMZSA-N
• Gene Information: human ... ADRB2(154)

Description

Application

ICI 118,551 hydrochloride has been used:

• to block β-adrenergic signaling in various experiments
• to counteract degradation by endogenous T-lymphocyte monoamine oxidases
• to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

ICI 118,551 hydrochloride is a highly selective β₂-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves