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Key Documents

AV50526

Sigma-Aldrich

Anti-APC2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-APCL, Anti-Adenomatosis polyposis coli 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

244 kDa

species reactivity

mouse, bovine, rat, dog, human, guinea pig

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_005874

UniProt accession no.

Q9UJX6

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APC2(10297)

Immunogen

Synthetic peptide directed towards the middle region of human APC2

Application

Anti-APC2 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml.

Biochem/physiol Actions

Adenomatosis polyposis coli 2 (APC2) is a tumor suppressor and a negative regulator of Wnt signaling pathway. The C-terminal of APC interacts with microtubules and is important for cytoskeletal regulation. The expression of APC2 and Axin protein is required to maintain the fidelity of mitosis as they regulate cytoskeleton and facilitate centrosome separation.

Sequence

Synthetic peptide located within the following region: LAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGP

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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John S Poulton et al.
Development (Cambridge, England), 140(20), 4226-4236 (2013-09-13)
To ensure the accurate transmission of genetic material, chromosome segregation must occur with extremely high fidelity. Segregation errors lead to chromosomal instability (CIN), with deleterious consequences. Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most colon cancers and
Shirin Bahmanyar et al.
Advances in experimental medicine and biology, 656, 65-74 (2009-11-26)
Adenomatous polyposis coli (APC) is a multifunctional protein commonly mutated in colon cancer. APC contains binding sites for multiple proteins with diverse roles in signaling and the structural and functional organization of cells. Recent evidence suggests roles for APC and
David M Roberts et al.
Molecular biology of the cell, 23(11), 2041-2056 (2012-04-20)
Wnt signaling plays key roles in development and disease. The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling. Its best-characterized role is as part of the destruction complex, targeting the Wnt effector β-catenin (βcat)

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