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A3846

Sigma-Aldrich

AL-8810

≥98% (HPLC), solid

Synonym(s):

(5Z, 13E)-(9S,11S,15R)-9,15,Dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid, [1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid

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About This Item

Empirical Formula (Hill Notation):
C24H31FO4
CAS Number:
246246-19-5
Molecular Weight:
402.50
MDL number:
MFCD04039992
UNSPSC Code:
51111800
PubChem Substance ID:
24278225
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: soluble 10 mg/mL
ethanol: soluble

storage temp.

2-8°C

SMILES string

O[C@H]1C[C@H](F)[C@H](\C=C\[C@H](O)C2Cc3ccccc3C2)[C@H]1C\C=C/CCCC(O)=O

InChI

1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1

InChI key

WTYSXBKKVNOOIX-JTGCGUAKSA-N

Gene Information

human ... PTGFR(5737)

Biochem/physiol Actions

AL-8810 is a novel prostaglandin F2α analog; selective FP prostanoid receptor antagonist.

Legal Information

Sold under license from Alcon.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dedmer Schaafsma et al.
Respiratory research, 6, 85-85 (2005-07-29)
In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previously found to be dependent on Rho-kinase and have also been associated with the
Evanthia Nikolopoulou et al.
Journal of lipid research, 55(12), 2479-2490 (2014-10-18)
Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid

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