MPC4NTR10

Multiscreen^® 96 well Plate, polycarbonate membrane

pore size 0.4 μm, non-sterile

• Synonym(s): 96-Well Plate
• UNSPSC Code: 41104923
• eCl@ss: 32039006
• NACRES: NB.22

Properties

• material: flat bottom wells; polycarbonate membrane; polystyrene
• Quality Level: 400
• description: This 96-well filter plate has a Polycarbonate membrane used for Permeability studies.
• sterility: non-sterile
• product line: MultiScreen^®
• feature: lid
• manufacturer/tradename: MultiScreen^®
• parameter: 100 μL sample volume (per well)
• technique(s): DNA purification: suitable; activity assay: suitable (with precipitations); ligand binding assay: suitable; parallel artificial membrane permeation assay (PAMPA): suitable; receptor binding assay: suitable
• plate size: 96 wells
• well maximum volume: 300 μL
• working volume: 125 μL
• pore size: 0.4 μm pore size
• application(s): sample preparation
• shipped in: ambient

Description

General description

Filter Code: PCF

Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput

Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1

PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3

MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.

Application

Research Category
Assays

Protein

Physical form

Color Code: Clear

Other Notes

Automation Compatible: No

Legal Information

MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany