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LM6003

Avanti

Cardiolipin Mix I

Avanti Polar Lipids

Synonym(s):

Cardiolipin Mix I, Cardiolipin Mixture Internal Standard

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About This Item

UNSPSC Code:
41116107
NACRES:
NA.25

form

methanol solution

packaging

pkg of 1 × 1 mL (LM6003-1EA)

manufacturer/tradename

Avanti Polar Lipids

concentration

~100 μg/mL (Refer to C of A for lot specific concentration. )

application(s)

lipidomics
metabolomics

shipped in

dry ice

storage temp.

−20°C

General description

Cardiolipin is an anionic phospholipid located in the inner mitochondrial membrane. It constitutes 20% of total lipids. The non-bilayer has four acyl chains and a small head group.

Application

Cardiolipin Mix I has been used as an internal standard in the mass-spectrometric analysis of phospholipids.

Biochem/physiol Actions

Cardiolipin plays a vital role in the organization of membranes and cell division. It regulates the proton uptake pathway. It contributes to mitochondrial biogenesis, fusion and fission, respiration and protein import. Cardiolipin controls cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.

Packaging

2 mL Amber Glass Sealed Ampule (LM6003-1EA)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The role of cardiolipin in cardiovascular health
Shen Z, et al.
BioMed Research International, 2015 (2015)
Acylglycerol kinase mutated in Sengers syndrome is a subunit of the TIM22 protein translocase in mitochondria
Vukotic M, et al.
Molecular Cell, 67(3), 471-483 (2017)
Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes
Miliara X, et al.
EMBO Reports, 16(7), 824-835 (2015)
MICOS and phospholipid transfer by Ups2--Mdm35 organize membrane lipid synthesis in mitochondria
Aaltonen MJ, et al.
The Journal of Cell Biology, 213(5), 525-534 (2016)
Role of cardiolipin in mitochondrial signaling pathways
Dudek J
Frontiers in Cell and Developmental Biology, 5, 90-90 (2017)
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