857125C

20:4 Lyso PA

1-arachidonoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), chloroform

• Synonym(s): arachidonoyl lysophosphatidic acid; 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate (ammonium salt); PA(20:4(5Z,8Z,11Z,14Z)/0:0); 20:4 LPA
• Empirical Formula (Hill Notation): C₂₃H₄₂NO₇P
• CAS Number: 799268-65-8
• Molecular Weight: 475.56
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• Assay: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• form: liquid
• packaging: pkg of 1 × 1 mL (857125C-10mg)
• manufacturer/tradename: Avanti Polar Lipids 857125C
• concentration: 10 mg/mL (857125C-10mg)
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@](COP([O-])(O)=O)([H])COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O.[NH4+]

Description

General description

Lysophosphatidic acid (LPA) is a lysophospholipid comprising of glycerol 3-phosphate (G3P), fatty acids, and phosphates.

Application

20:4 Lyso PA (LPA) has been used in feeding low density lipoprotein receptor null (LDLR^-/-) mice. It is suitable for use as standard for high performance liquid chromatography (HPLC) and liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) for the quantification of human plasma LPA, and as a strong agonist for lysophosphatidic acid receptor1(LPA₁).

Biochem/physiol Actions

Lysophosphatidic acid (LPA) is a bioactive lipid produced in tissues. LPA is involved in signal transduction through G-protein coupled receptors. LPA is implicated in many diseases including atherosclerosis, ischaemia perfusion injury, thrombosis and hypertension. LPA also plays an important role in wound healing processes, autoimmune diseases and tumor metastasis.

Packaging

5 mL Clear Glass Sealed Ampule (857125C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412
• Precautionary Statements: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): does not flash
• Flash Point(C): does not flash