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810180C

Avanti

TopFluor™ TMR PC

Avanti Research™ - A Croda Brand 810180C

Synonym(s):

1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C53H82 BF2N4 O10P
CAS Number:
2260795-27-3
Molecular Weight:
1015.02
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810180C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810180C

concentration

1 mg/mL (810180C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Tetramethylrhodamine (TMR) phosphatidylcholine (PC) is an acyl-chain-modified fluorescently labeled phospholipid. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotes and a prime metabolite of glycerolipid metabolism.

Application

TopFluor™ TMR PC or 1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine has been used to label biotinylated giant plasma membrane vesicles (GPMV). It is also suitable for the formation of lipid membranes in microarrays.

Biochem/physiol Actions

TopFluor™-labeled lipids have spectral properties similar to tetramethylrhodamine (TMR).

Packaging

5 mL Amber Glass Screw Cap Vial (810180C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Single-molecule analysis of phospholipid scrambling by TMEM16F
Rikiya W, et al.
Proceedings of the National Academy of Sciences of the USA, 115(12), 3066-3071 (2018)
Rikiya Watanabe et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(12), 3066-3071 (2018-03-07)
Transmembrane protein 16F (TMEM16F) is a Ca2+-dependent phospholipid scramblase that translocates phospholipids bidirectionally between the leaflets of the plasma membrane. Phospholipid scrambling of TMEM16F causes exposure of phosphatidylserine in activated platelets to induce blood clotting and in differentiated osteoblasts to
Libing Mu et al.
Nature communications, 9(1), 4259-4259 (2018-10-17)
Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling is well-studied, how it originated from ancient phagocytosis is unknown. Lipid redistribution upregulates a phagocytic program recapitulating FcR-based phagocytosis with complete dependence

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