700137P
Avanti
7β,27-dihydroxycholesterol-d6
Avanti Polar Lipids 700137P, powder
Synonym(s):
7β,27-dihydroxycholesterol-d6
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About This Item
Empirical Formula (Hill Notation):
C27H40D6O3
CAS Number:
Molecular Weight:
424.69
UNSPSC Code:
41141804
NACRES:
NA.25
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700137P-1mg)
manufacturer/tradename
Avanti Polar Lipids 700137P
shipped in
dry ice
storage temp.
−20°C
General description
7β,27-dihydroxycholesterol-d6 is a deuterated derivative of 7β,27-dihydroxycholesterol. 7β,27-dihydroxycholesterol is a substrate for enzyme 11β-hydroxysteroid dehydrogenases (11β-HSDs).
Application
7β,27-dihydroxycholesterol-d6 has been used as an internal standard in ultra-performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS).
Biochem/physiol Actions
7β,27-dihydroxycholesterol (7β27OHC) serves as a ligand for retinoid-related orphan receptor γ (RORγ). 7β27OHC is also involved in smoothened (Smo) functionality.
Packaging
5 mL Amber Glass Screw Cap Vial (700137P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Katharina R Beck et al.
Journal of lipid research, 60(9), 1535-1546 (2019-07-06)
Oxysterols previously were considered intermediates of bile acid and steroid hormone biosynthetic pathways. However, recent research has emphasized the roles of oxysterols in essential physiologic processes and in various diseases. Despite these discoveries, the metabolic pathways leading to the different
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