47633

Fmoc-Leu-OH

≥97.0%

• Synonym(s): N-(9-Fluorenylmethoxycarbonyl)-L-leucine, Fmoc-L-leucine
• Empirical Formula (Hill Notation): C₂₁H₂₃NO₄
• CAS Number: 35661-60-0
• Molecular Weight: 353.41
• Beilstein: 2178254
• EC Number: 252-662-7
• MDL number: MFCD00037133
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 57651051
• NACRES: NA.26

Properties

• Assay: ≥97.0%
• optical activity: [α]20/D −25±2°, c = 1% in DMF
• reaction suitability: reaction type: C-H Activation; reaction type: Fmoc solid-phase peptide synthesis; reagent type: ligand; reaction type: Peptide Synthesis
• mp: 152-156 °C (lit.); 152-156 °C
• application(s): peptide synthesis
• functional group: Fmoc; amine; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
• InChI: 1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1
• InChI key: CBPJQFCAFFNICX-IBGZPJMESA-N

Description

Application

Fmoc-Leu-OH can be used as a reactant to synthesize:

• Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
• A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
• Streptocidin A−D, decapeptide antibiotics naturally found in Streptomyces sp. Tü 6071.
• Coumaroyl dipeptide amide that can be used for cosmetic applications.

Biochem/physiol Actions

PPARγ ligand that induces insulin sensitization, but not adipogenesis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves