20615

2-tert-Butyl-1,1,3,3-tetramethylguanidine

≥97.0% (GC)

• Synonym(s): BTMG
• Empirical Formula (Hill Notation): C₉H₂₁N₃
• CAS Number: 29166-72-1
• Molecular Weight: 171.28
• Beilstein: 2352408
• MDL number: MFCD01862972
• UNSPSC Code: 12352100
• PubChem Substance ID: 57647848
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: ≥97.0% (GC)
• form: liquid
• refractive index: n20/D 1.457
• bp: 88-89 °C/43 mmHg (lit.)
• SMILES string: CN(C)\C(=N/C(C)(C)C)N(C)C
• InChI: 1S/C9H21N3/c1-9(2,3)10-8(11(4)5)12(6)7/h1-7H3
• InChI key: YQHJFPFNGVDEDT-UHFFFAOYSA-N

Description

General description

2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.

Application

• Synthesis of dinaphthyl ethers: Barton′s base, which includes 2-tert-Butyl-1,1,3,3-tetramethylguanidine, was utilized to promote SNAr reactions for the synthesis of highly oxygenated dinaphthyl ethers, demonstrating its efficacy as a catalyst in complex organic synthesis processes (Wipf and Lynch, 2003).

Caution

Remark on appearance: Material may form precipitate on storage. The precipitate may easily be separated by filtration.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302 - H314
• Precautionary Statements: P260 - P280 - P301 + P312 + P330 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Skin Corr. 1B
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 149.0 °F - closed cup
• Flash Point(C): 65.0 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves