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SRP6552

Sigma-Aldrich

TGF-β3 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):

Transforming growth factor beta-3

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

liquid

mol wt

25.5 kDa

packaging

pkg of 5 μg
pkg of 50 μg
pkg of 500 μg

concentration

0.25 mg/mL

impurities

≤1 EU/μg endotoxin (LAL test)

UniProt accession no.

P04202 

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... TGF-beta-1(21803)

General description

TGFβ3 (transforming growth factor β3) is one of the three isoforms of mammalian TGFβ, and all the isoforms share high sequence similarity at the active domains, with TGFβ3 showing highest similarity with TGFβ1.
Recombinant mouse TGF-β3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains, with a total molecular weight of 25.5kDa.
The TGFB1 gene is mapped to human chromosome 19q13.2. The encoded protein is an anti-inflammatory cytokine.

Biochem/physiol Actions

TGFβ3 (transforming growth factor β3) shows higher expression levels during late stage tumors, and hence, is thought to be associated with tumorigenesis. However, studies also show that in skin, breast, oral and gastric mucosa and other types of tissue, this protein confers protection against tumorigenesis. It plays crucial role in the development of systems such as heart, breast and lung. It is essential for mouse embryonic palate fusion, as inactivation results in non-fusion of palatal shelves. This protein plays a crucial role in orofacial development and is essential for excisional wound repair in vivo.

Physical form

0.25 mg/mL solution containing 20% ethanol and 0.12% acetic acid (AcOH) .

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

does not flash

Flash Point(C)

does not flash

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Peripheral regulatory T cells and anti-inflammatory cytokines in children with juvenile idiopathic arthritis
Sznurkowska K, et al.
Acta Biochimica Polonica, 65(1), 1908-1916 (2018)
TGF-beta3 and cancer: a review.
Laverty HG et al
Cytokine & Growth Factor Reviews, 20(4), 305-317 (2009)
Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
Le M et al
PLoS ONE, 7(10), e48040-e48040 (2012)
Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
Begum A, et al.
Cancer Science, 100(10), 1908-1916 (2009)
Zhaoyang Liu et al.
PLoS genetics, 15(10), e1008096-e1008096 (2019-10-28)
Degenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide and has been attributed primarily to trauma and the accumulation of pathology during aging. While genetic defects have also been associated with disc degeneration
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