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GW22895

Sigma-Aldrich

Anti-RGS18 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Regulator of G-protein signaling 18

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
conjugate:
unconjugated
application:
WB
clone:
polyclonal
species reactivity:
rat, human, mouse
citations:
3
technique(s):
western blot: suitable

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

manufacturer/tradename

Genway 15-288-22895

technique(s)

western blot: suitable

NCBI accession no.

NP_570138.1

UniProt accession no.

Q9NS28

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RGS18(64407)

Immunogen

Immunogen Sequence: GI # 18640750, sequence 11-100
Recombinant regulator of G-protein signalling 18

Application

Anti-RGS18 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Regulator of G-protein signaling 18 is a protein encoded by the RGS18 gene in humans. It is a GTPase-activating protein for the G-α-q and G-α-i subunits of heterotrimeric G-proteins that turns off signaling by G-protein coupled receptors. It is highly expressed in platelets. RGS18 can act on G(q)-mediated signaling pathways. It is expressed most highly in megakaryocytes and can modulate GPCR pathways in both mammalian and yeast cells. RGS18 may have an important role in the regulation of megakaryocyte differentiation and chemotaxis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
039K1902
039K1896
029K2122

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Kristina Gegenbauer et al.
Blood, 119(16), 3799-3807 (2012-01-12)
Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein for the G-α-q and G-α-i subunits of heterotrimeric G-proteins that turns off signaling by G-protein coupled receptors. RGS18 is highly expressed in platelets. In the present study, we show that
I K Park et al.
The Journal of biological chemistry, 276(2), 915-923 (2000-10-24)
A novel regulator of G-protein signaling (RGS) has been isolated from a highly purified population of mouse long-term hematopoietic stem cells, and designated RGS18. It has 234 amino acids consisting of a central RGS box and short divergent NH(2) and
D Yowe et al.
The Biochemical journal, 359(Pt 1), 109-118 (2001-09-21)
Myelopoiesis and lymphopoiesis are controlled by haematopoietic growth factors, including cytokines, and chemokines that bind to G-protein-coupled receptors (GPCRs). Regulators of G-protein signalling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. We

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