Initiation of DNA replication requires actin dynamics and formin activity.

Initiation of DNA replication requires actin dynamics and formin activity.

The EMBO journal (2017-10-07)

Nikolaos Parisis, Liliana Krasinska, Bethany Harker, Serge Urbach, Michel Rossignol, Alain Camasses, James Dewar, Nathalie Morin, Daniel Fisher

PMID28982779

RESUMEN

Nuclear actin regulates transcriptional programmes in a manner dependent on its levels and polymerisation state. This dynamics is determined by the balance of nucleocytoplasmic shuttling, formin- and redox-dependent filament polymerisation. Here, using

MATERIALES

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A2066

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Anti--actina antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

L5163

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Latrunculin A, from sea sponge, ≥85% (HPLC), waxy solid

NA03

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Anti-PCNA (Ab-1) Mouse mAb (PC10), liquid, clone PC10, Calbiochem^®

P7962

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