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Key Documents

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Z4277

Sigma-Aldrich

Zileuton

≥98% (HPLC)

Sinónimos:

(±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea

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About This Item

Fórmula empírica (notación de Hill):
C11H12N2O2S
Número de CAS:
111406-87-2
Peso molecular:
236.29
MDL number:
MFCD00866097
UNSPSC Code:
12352200
PubChem Substance ID:
329831613
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL at ~60 °C (warm up to 60 C for 5min)

originator

Abbott

storage temp.

room temp

SMILES string

CC(N(O)C(N)=O)c1cc2ccccc2s1

InChI

1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)

InChI key

MWLSOWXNZPKENC-UHFFFAOYSA-N

Gene Information

human ... ALOX5(240)

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Biochem/physiol Actions

Zileuton is an anti-asthmatic, an inhibitor of 5-lipoxygenase; the initial enzyme in the biosynthesis of leukotrienes from arachidonic acid.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Norwin Kubick et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-10)
Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression is a significant type of mood disorder, where patients suffer from pathological disturbances associated with a proinflammatory M1 macrophage phenotype. Presently
Kaneez Fatima et al.
Frontiers in nutrition, 9, 857256-857256 (2022-04-26)
Carvacrol, a monoterpene known for its pharmacological activities, is present in the essential oil of Origanum majorana, Origanum vulgare, Thymus vulgaris, and Lippia graveolens. It is used in food as a flavoring and preservative agent in cosmetics and medicines because
Ju Youn Lee et al.
Nature communications, 11(1), 2358-2358 (2020-05-14)
Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer's disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated
M Bessadóttir et al.
Prostaglandins, leukotrienes, and essential fatty acids, 98, 39-47 (2015-05-13)
Lipoxygenases (LOXs) and their products are involved in several biological functions and have been associated with carcinogenesis. Protolichesterinic acid (PA), a lichen metabolite, inhibits 5- and 12-LOX and has anti-proliferative effects on various cancer cell lines. Here, PA was shown
Tsugunobu Andoh et al.
Journal of dermatological science, 76(3), 206-213 (2014-12-03)
Phosphodiesterase 4 (PDE4), which catalyses the conversion of cyclic adenosine 3',5'-monophosphate (cAMP) to 5'-AMP, plays a critical role in the pathogenesis of inflammatory disorders. Pruritus is the main symptom of dermatitides, such as atopic dermatitis, and is very difficult to

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