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UC432

Sigma-Aldrich

AAMU

Sinónimos:

5-Acetylamino-6-amino-3-methyluracil, N-(4-Amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)acetimide

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About This Item

Fórmula empírica (notación de Hill):
C7H10N4O3
Número de CAS:
19893-78-8
Peso molecular:
198.18
MDL number:
MFCD01310688
UNSPSC Code:
12161501
PubChem Substance ID:
24724657
NACRES:
NA.77

form

solid

color

white to light pink

mp

≥305 °C

storage temp.

2-8°C

SMILES string

CN1C(=O)NC(N)=C(NC(C)=O)C1=O

InChI

1S/C7H10N4O3/c1-3(12)9-4-5(8)10-7(14)11(2)6(4)13/h8H2,1-2H3,(H,9,12)(H,10,14)

InChI key

POQOTWQIYYNXAT-UHFFFAOYSA-N

Application

CYP1A2 metabolite of caffeine

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

related product

Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
1385529
065K32641
065K3264

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Y Kawakubo et al.
Dermatology (Basel, Switzerland), 195(1), 43-45 (1997-01-01)
p-Phenylenediamine (PPD) has been widely distributed as hair dye ingredient and may be responsible for contact dermatitis. Since not all the subjects exposed to PPD react to the substance, we tested a possible predisposing factor of cutaneous drug metabolism. Eighty-five
P Wong et al.
Journal of pharmaceutical and biomedical analysis, 13(9), 1079-1086 (1995-08-01)
The ratio of 5-acetylamino-6-amino-3-methyluracil (AAMU) to 1-methylxanthine (1X) in urine samples after caffeine ingestion can be used to indicate human N-acetyltransferase (NAT2) phenotypes. In previous studies, this ratio has been determined by LC or capillary electrophoresis. The possibility that this
B K Tang et al.
Clinical pharmacology and therapeutics, 49(6), 648-657 (1991-06-01)
The use of two caffeine metabolite ratios for acetylator phenotyping was validated by demonstrating concordance with two sulfamethazine tests in 178 unrelated healthy subjects. The caffeine metabolites used for this purpose were 5-acetylamino-6-amino-3-methyluracil (AAMU), 1-methylxanthine (1X), and 1-methylurate (1U). The
B K Tang et al.
Clinical pharmacology and therapeutics, 42(5), 509-513 (1987-11-01)
Previously published methods allow the determination of the genetically controlled acetylator status using caffeine as a test drug, based on the urinary excretion of a ring-opened metabolite of caffeine, an acetylated uracil (5-acetylamino-6-formylamino-3-methyluracil). 5-Acetylamino-6-formylamino-3-methyluracil is labile but can be converted
A J Kilbane et al.
Clinical pharmacology and therapeutics, 47(4), 470-477 (1990-04-01)
The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achieved by adding
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