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U2875

Sigma-Aldrich

Uric acid sodium salt

Sinónimos:

2,6,8-Trihydroxypurine, Sodium acid urate

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About This Item

Fórmula lineal:
C5H3N4O3Na
Número de CAS:
1198-77-2
Peso molecular:
190.09
EC Number:
214-838-1
MDL number:
MFCD00067310
UNSPSC Code:
41106305
PubChem Substance ID:
24900636
NACRES:
NA.51

biological source

microbial
synthetic

assay

11.0-13.0% anhydrous basis (Sodium, ICP)

form

powder

solubility

1 M NaOH: 25 mg/mL, clear, colorless to faintly yellow

SMILES string

[Na].O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3.Na.H/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;

InChI key

IHMJZGFANDMEJM-UHFFFAOYSA-N

Categorías relacionadas

Application

Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

Biochem/physiol Actions

Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid. Sodium urate has been shown to precipitate calcium oxalate from urine. It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity. Excess sodium urate in soft tissues results in a condition referred to as tophi.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jieru Han et al.
Journal of natural medicines, 75(1), 37-47 (2020-08-08)
Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not been fully understood. In the
A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog
Toutain PL, et al.
Journal of Veterinary Pharmacology and Therapeutics, 24(1), 43-55 (2001)
Bin Zhang et al.
Cellular and molecular neurobiology, 37(5), 931-939 (2016-10-07)
Cerebral infarction (CI) is a common clinical cerebrovascular disease, and to explore the pathophysiological mechanisms and seek effective treatment means are the hotspot and difficult point in medical research nowadays. Numerous studies have confirmed that uric acid plays an important
Effects of reactive metabolites of oxygen and nitrogen on gelatinase A activity
Owens MW, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 273(2), L445-L450 (1997)
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