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MilliporeSigma

T5067

Sigma-Aldrich

Anti-TRPC3 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-Transient receptor potential cation channel, subfamily C, member 3

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

concentration

≥0.6 mg/mL (after reconstitution)

technique(s)

western blot: suitable

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Trpc3(22065)
rat ... Trpc3(60395)

General description

Transient receptor potential-canonical 3 (TRPC3) is a member of TRP superfamily. It is mainly expressed in brain. The TRPC3 gene is mapped to human chromosome 4.

Immunogen

peptide corresponding to amino acid residues 822-835 of mouse TRPC3.

Biochem/physiol Actions

TRPC3 (transient receptor potential-canonical 3) participates in motility and capacitation of sperm. It is responsible for the proliferation of ovarian cancer cell in vitro and in vivo. TRPC3 plays a key role in a wide spectrum of Ca2+ signaling mechanisms. Elevated expression of TRPC3 has been observed in spontaneously hypertensive rats (SHR).

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

TRPC3: A Multifunctional Signaling Molecule
Lichtenegger M and Groschner K
Handbook of Experimental Pharmacology, 67-84 (2014)
Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter.
Martin-Trujillo A
Epigenetics, 6, 1236-1241 (2011)
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li HS
Neuron, 24, 261-273 (1999)
Increased Transient Receptor Potential Channel TRPC3 Expression in Spontaneously Hypertensive Rats
Liu D
American Journal of Hypertension, 18, 1503-1507 (2005)
Follicle-stimulating hormone enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3
Tao X
Endocrine-Related Cancer, 20, 415-429 (2013)

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