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T4009

Sigma-Aldrich

Ácido taurocólico sodium salt hydrate

≥95% (HPLC)

Sinónimos:

Taurocolato de sodio hydrate, Ácido 2-[(3α,7α,12α-Trihidroxi-24-oxo-5β-colan-24-il) amino] etanosulfónico, Ácido 3α,7α,12α-trihidroxi-5β-colan-24-oico N-(sulfoetil)amida

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About This Item

Fórmula empírica (notación de Hill):
C26H44NNaO7S · xH2O
Número de CAS:
345909-26-4
Peso molecular:
537.68 (anhydrous basis)
EC Number:
205-653-7
MDL number:
MFCD00150819
UNSPSC Code:
12161900
PubChem Substance ID:
24900186
NACRES:
NA.25

biological source

synthetic (organic)

Quality Level

200

description

anionic

assay

≥95% (HPLC)

form

powder

mol wt

micellar avg mol wt 2100

aggregation number

4

CMC

3-11 mM (20-25°C)

functional group

sulfonic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[H]O[H].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@H](CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCS([O-])(=O)=O

InChI

1S/C26H45NO7S.Na.H2O/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1

InChI key

RDAJAQDLEFHVNR-NEMAEHQESA-M

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General description

Taurocholic acid sodium salt hydrate is a bile acid with detergent capabilities.

Application

Taurocholic acid sodium salt hydrate has been used in a study to assess the adsorption of bile acids and salts to vegetable fibrous tissue. It has also been used in a study to investigate a method for determination of conjugated and unconjugated bile salts in serum and jejunal fluid.
Detergente aniónico utilizado para solubilización de proteínas.

Biochem/physiol Actions

Sal biliar no sulfatada, sustrato de transporte fisiológico para la bomba de exportación de sales biliares/hermana de Pgp (BSEP/spgp), cotransportador de Na(+)/taurocolato (NTCP) y MRP3 en los canalículos hepáticos.

Preparation Note

Synthesized from cholic acid

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Joseph J Orsini et al.
Clinica chimica acta; international journal of clinical chemistry, 413(15-16), 1270-1273 (2012-05-03)
We sought to modify a previously published tandem mass spectrometry method of screening for 5 lysosomal storage disorders (LSDs) in order to make it better suited for high-throughput newborn screening. Two 3-mm dried blood spot (DBS) punches were incubated, each
Studies on the adsorption of bile salts to non-absorbed components of diet.
M A Eastwood et al.
Biochimica et biophysica acta, 152(1), 165-173 (1968-01-10)
A Tangerman et al.
Clinica chimica acta; international journal of clinical chemistry, 159(2), 123-132 (1986-09-15)
A reliable method is described for the determination of conjugated and unconjugated bile acids in serum and jejunal fluid. Bile acids are extracted using reverse-phase octadecylsilane bonded silica cartridges and are separated into their unconjugated and conjugated fractions using the
Theresa D Ho et al.
Infection and immunity, 82(6), 2345-2355 (2014-03-26)
Clostridium difficile is a clinically important pathogen and the most common cause of hospital-acquired infectious diarrhea. Expression of the C. difficile gene csfV, which encodes σ(V), an extracytoplasmic function σ factor, is induced by lysozyme, which damages the peptidoglycan of
Studies on the Antibacterial Properties of the Bile Acids and some Compounds Derived from Cholanic Acid
M. Stacey and M. Webb
Proc. Royal Soc. Lond. B., 134, 523-523 (1947)
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