SRP6519
Lactoferrin from human milk
≥95% (SDS-PAGE)
Sinónimos:
Lactotransferrin, Talalactoferrin
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About This Item
UNSPSC Code:
12352202
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General description
Lactoferrin gene is mapped to human chromosome 3p21.31.
Lactoferrin is a glycoprotein present in exocrine secretions and in the secondary granules of polymorphonuclear neutrophils. It is the iron binding protein in milk. Human lactoferrin belongs to the family of transferrins. It is found to be expressed in several glandular epithelial cells and skin epidermal keratinocytes.
Application
Lactoferrin from human milk has been used as a standard in standard curve generation for quantifying recombinant lactoferrin in enzyme-linked immunosorbent assay (ELISA). It has also been used as a positive control in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE ).
Biochem/physiol Actions
Lactoferrin is known to regulate intestinal iron absorption, and to participate in the defense against bacteria. It functions in the innate immune system via the activation of nuclear factor-κB (NF-κB). This activation occurs via Toll-like receptor 4 pathway due to the interference of lactoferrin with the lipopolysaccharide-stimulated TLR4 signaling. It serves as a ligand for low-density lipoprotein receptor-related protein 1 (LRP1) in human skin keratinocytes and fibroblasts. It is capable of stimulating cell growth in various cell lines. Lactoferrin is also found to participate in wound healing.
Physical form
Frozen in 50 mM Tris and 0.2 M NaCl, pH 8.0 .
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Pediatrics, 75, 172-176 (1985)
L Tang et al.
The British journal of dermatology, 163(1), 38-47 (2010-03-13)
Human lactoferrin (hLF), a member of the transferrin family, is known for its antimicrobial and anti-inflammatory effects. Recent studies on various nonskin cell lines indicate that hLF may have a stimulatory effect on cell proliferation. To study the potential role
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U N Wiesmann et al.
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