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Key Documents

SRP6507

Sigma-Aldrich

Haptoglobin (Phenotype 1-1) from human plasma

≥95% (SDS-PAGE)

Sinónimos:

Hp 1-1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human plasma

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

86 kDa

packaging

pkg of 1 mg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HP(3240)

General description

Haptoglobin is a positive acute-phase plasma α2-sialoglycoprotein, and exists as three major phenotypes namely Hp 1-1, Hp 2-1, and Hp 2-2. Haptoglobin is composed of heavy β- (40 kDa) and light α- (α1= 8.9kDa and α2= 16kDa) chains. Hp 1-1 is the smallest phenotype with a molecular weight of 86kDa, and is composed of only α1.

Biochem/physiol Actions

Haptoglobin functions as an antioxidant by binding free hemoglobin, and eliminates it from circulation to prevent iron loss and renal injury following hemolysis. It is responsible for maintaining the helper T-cell type 1 and type 2 (Th1/Th2) balance, and functions as an immunosuppressor of lymphocyte function. It also functions as an angiogen and anti-inflammatory agent. Hp 1-1 phenotype is most effective in binding free hemoglobin and preventing inflammatory responses linked with free hemoglobin. Studies show that all the three phenotypes of haptoglobin are involved in idiopathic generalized epilepsy.

Physical form

Lyophilized as a salt-free solid.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Haptoglobin phenotypes in epilepsy.
Sadrzadeh SM, et al.
Clinical Chemistry, 50(6), 1095-1097 (2004)
Determination of haptoglobin genotype in an Iranian population with idiopathic generalized epilepsy.
Al-Balaghee S et al
Reports of Biochemistry and Molecular Biology, 3(2), 51-55 (2015)
Haptoglobin phenotypes in health and disorders.
Sadrzadeh SM, Bozorgmehr J, et al.
American Journal of Clinical Pathology, 121, S97-104 (2004)
Fabiana Baganha et al.
International journal of molecular sciences, 23(21) (2022-11-12)
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