SRP5316
RIPK3, active, GST tagged human
PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
RIP3
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About This Item
Productos recomendados
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO®
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
30-51 nmol/min·mg
mol wt
~96 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RIPK3(11035)
General description
Receptor interacting serine/threonine kinase 3 (RIPK3)/RIP3 is a serine/threonine kinase. It belongs to the receptor-interacting protein family. RIPK3 is characterized with a conserved amino-terminal kinase domain, which is necessary for necrosis. The gene RIPK3 is mapped to human chromosome 14. The encoded protein is composed of 518 amino acids.
Biochem/physiol Actions
Receptor interacting serine/threonine kinase 3 (RIPK3) activates necroptotic cell death and has a role in inflammatory signaling. The protein also functions in controlling viral infections, platelet functions, hemostasis and thrombosis. RIPK3 is highly expressed during cutaneous wound repair and also stimulates interleukin-1 β production.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Preparation Note
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
RIP3: a molecular switch for necrosis and inflammation.
Moriwaki K and Chan F K M
Genes & Development, 27(15), 1640-1649 (2013)
Expression Profile and Tissue-Specific Distribution of the Receptor-Interacting Protein 3 in BALB/c Mice.
Wang Q, et al.
Biochemical Genetics, 54(4), 360-367 (2016)
Receptor-interacting protein kinase 3 deficiency delays cutaneous wound healing.
Godwin A, et al.
PLoS ONE, 10(10), e0140514-e0140514 (2015)
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation.
Daniels B P, et al.
Cell, 169(2), 301-313 (2017)
Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis.
Zhang Y, et al.
Proceedings of the National Academy of Sciences of the USA, 114(11), 2964-2969 (2017)
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