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SRP2053

USF1 human

Name: USF1 human
Brand: SIGMA

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Sinónimos:

FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.26

biological source

human

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~35.1 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

600 μg/mL

color

clear colorless

NCBI accession no.

NM_007122

UniProt accession no.

P22415

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... USF1(7391)

Biochem/physiol Actions

Human Upstream Stimulatory Factor 1 (USF1) regulates the transcription of many genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia (FCHL) and type 2 diabetes on chromosome 1q22-23. The USF1 protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. It is a basic helix-loop-helix leucine zipper (b-HLH-ZIP) protein that shares a common DNA-binding specificity with the c-Myc oncoproteins.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Human transcription factor USF stimulates transcription through the initiator elements of the HIV-1 and the Ad-ML promoters.

H Du et al.

The EMBO journal, 12(2), 501-511 (1993-02-01)

Earlier in vitro studies identified USF as a cellular factor which activates the adenovirus major late (Ad-ML) promoter by binding to an E-box motif located at position -60 with respect to the cap site. Purified USF contains 44 and 43

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

Päivi Pajukanta et al.

Nature genetics, 36(4), 371-376 (2004-03-03)

Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total cholesterol, triglycerides or both, is observed in about 20% of individuals with premature coronary heart disease. We previously identified a locus linked to FCHL on 1q21-q23 in Finnish families

Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.

Wendy Putt et al.

Human molecular genetics, 13(15), 1587-1597 (2004-06-04)

Upstream stimulatory factor 1 (USF 1), is a transcription factor controlling expression of several genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia (FCHL) and type 2 diabetes on chromosome 1q22-23. We sequenced USF1 in 24

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